5-Bromo-1-methyl-1H-benzo[d]imidazole

5-Bromo-1-methyl-1H-benzo[d]imidazole - Names and Identifiers

Name	5-Bromo-1-methyl-1H-benzo[d]imidazole
Synonyms	5-Bromo-1-methylbenzimidazole 5-BROMO-1-METHYL-1H-BENZIMIDAZOLE 1H-Benzimidazole, 5-bromo-1-methyl- 5-bromo-1-methyl-1H-1,3-benzodiazole 5-Bromo-1-methyl-1H-benzo[d]imidazole
CAS	53484-15-4

5-Bromo-1-methyl-1H-benzo[d]imidazole - Physico-chemical Properties

Molecular Formula	C8H7BrN2
Molar Mass	211.06
Density	1.60
Boling Point	317.2±34.0 °C(Predicted)
pKa	4.56±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature

5-Bromo-1-methyl-1H-benzo[d]imidazole - Reference Information

application

5-bromo -1-methylbenzimidazole can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical generation process.

preparation

100 mL three-neck bottle plus (26 mmol) compound 5-bromo -2-(methylamino) aniline and 50 mL xylene, the resulting suspension plus triethyl orthoformate (7. 7
mmol), heated and refluxed for 7 h. After cooling, the solid is dissolved in 90 mL of dichloromethane, and the obtained dichloromethane solution is washed once by 50 mL 10% potassium carbonate and 50 mL
saturated salt water, anhydrous magnesium sulfate is dried, and the solvent is distilled under reduced pressure. The filtrate is concentrated to dry, and the resulting solid is also dissolved in dichloromethane, washed and dried in the same way to recover organic matter. Combined organic matter, silica gel column chromatography, eluent: petroleum ether/ethyl acetate (3
∶ 1), 5-bromo-1-methylbenzimidazole 6.5g, the yield is 87%.

Last Update：2024-04-09 20:52:54